Frequently Asked Questions
What are the benefits of a mucoadhesive gel?
BlisselⓇ has a mucoadhesive formulation which works synergistically with the estriol, providing both a moisturising effect and increasing the retention and penetration of the hormone.1
How does BlisselⓇ differ from a cream formulation?
BlisselⓇ is formulated as a mucoadhesive gel rather than a cream. Non-mucoadhesive products may have shorter vaginal contact times and produce leakage.1
What are the benefits of using an ultra low dose preparation like BlisselⓇ?
Low dose estriol formulations, such as BlisselⓇ, have significantly lower systemic absorption of the hormone than higher dose medications.2
Why does BlisselⓇ use an applicator?
The applicator allows the patient to place the dose of BlisselⓇ gently in the correct location with minimal mess. The applicator can be cleaned and reused, reducing waste.
Are there other products that are formulated like BlisselⓇ?
BlisselⓇ is the only mucoadhesive gel hormonal preparation available on prescription to treat vaginal atrophy.3
What dose of estriol does BlisselⓇ contain?
BlisselⓇ is an ultra low dose estriol vaginal gel, containing 50 micrograms/g of estriol.3,4
How long does BlisselⓇ take to have an effect?
BlisselⓇ has been shown to produce a rapid improvement in symptoms, sometimes from the initial days of treatment.1
What are the physiological effects of BlisselⓇ?
BlisselⓇ treats the cellular changes that lead to vaginal atrophy, leading to a significantly higher maturation value of the vaginal tissue compared to placebo (p<0.001) after 12 weeks of treatment. 4 BlisselⓇ also reverses the changes in pH that occur in vaginal atrophy, with a significantly lower vaginal pH compared to placebo (p<0.001) after 12 weeks of treatment.4
What effect does BlisselⓇ have on the signs of vaginal atrophy?
BlisselⓇ leads to a significant improvement in the signs of vaginal atrophy, including mucosal dryness (p=0.04), flattening of folds (p<0.001), pallor (p<0.001) and vaginal fragility (p=0.006).4
What effect can BlisselⓇ have on my patient’s symptoms?
BlisselⓇ leads to a significant overall improvement in symptoms (significantly lower Global Symptom Score vs placebo (p=0.02) at week 12) and improves or completely resolves vaginal dryness in over 88% of women (P = 0.001; relative risk [RR], 1.32; CI, 1.08-1.62).4
- Lázaro-Carrasco de la Fuente J, et al. J Menopausal Med. 2022;28(2):60-69. 2. Delgado JL, et al. Climacteric. 2016;19(2):172-80. 3. Blissel 50 micrograms/g vaginal gel. Summary of Product Characteristics. 4. Cano A, et al. Menopause. 2012;19(10):1130-9.
Summary of Product Characteristics can be found at www.medicines.ie
The information on this website is intended for Republic of Ireland residents only.
IE-CH-1365 Date of Preparation August 2023
